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Tag: Formalin Fixed Paraffin Embedded Tissue

What Is Formalin Fixed Paraffin Embedded Tissue?

Formalin-fixed paraffin fabrics or FFPE fabrics are valuable for therapeutic and research applications. FFPE is a specialized technique for preparing and storing tissue samples used in research, research, diagnosis, and drug development. Tissue is first taken from a sick and uninfected donor. 

The paraffin-embedded membrane is first preserved through a process called formalin fixation. This step helps maintain vital structures and proteins in the tissues. It is then embedded in a paraffin block and cut into the necessary slices, mounted on a microscopic object, and examined.

FFPE Tissue

Image Source: Google

The process begins with sample selection and subsequent excision by the donor or patient. Samples can also be taken from other animals such as snakes, mice, or many others. After excision, the tissue is immersed in 10% neutral buffered formalin for approximately 18 to 24 hours. The tissue was then dehydrated using an increasing concentration of ethanol. 

The network is then embedded in paraffin to convert it into FFPE blocks. The method used will depend on the requirements of the researcher or physician requesting the FFPE sample. It is important to match the specifications for the problem, size, and intended use of the fabric. After the procedure is complete, a certified pathologist will assess the quality of the sample.


FFPE samples can be stored in hospitals, biobanks, and research centers. Storage facilities often keep records of how the tissue was collected, storage procedures, and demographic information of the donor. Demographic information is an important factor in research and clinical trials. Properly stored FFPE samples are invaluable and can be stored for a long time at room temperature.

Applications Of FFPE:

  • Immunohistochemistry
  • Oncology
  • Hematology
  • Immunology